How Darwin's “endless forms most beautiful” have evolved remains one of the most exciting questions in biology. The significant variety of bacterial shapes is most likely due to the specific advantages they confer with respect to the diverse environments they occupy. While our understanding of the mechanisms generating relatively simple shapes has improved tremendously in the last few years, the molecular mechanisms underlying the generation of complex shapes and the evolution of shape diversity are largely unknown. The emerging field of (...) bacterial evolutionary cell biology provides a novel strategy to answer this question in a comparative phylogenetic framework. This relatively novel approach provides hypotheses and insights into cell biological mechanisms, such as morphogenesis, and their evolution that would have been difficult to obtain by studying only model organisms. We discuss the necessary steps, challenges, and impact of integrating “evolutionary thinking” into bacterial cell biology in the genomic era. (shrink)

We propose that synesthetic cross‐activation between the primary auditory cortex and the anatomically adjacent insula may help explain two puzzling conditions—autonomous sensory meridian response (ASMR) and misophonia—in which quotidian sounds involuntarily trigger strong emotional responses. In ASMR the sounds engender relaxation, while in misophonia they trigger an aversive response. The insula both plays an important role in autonomic nervous system control and integrates multiple interoceptive maps representing the physiological state of the body to substantiate a dynamic representation of emotional wellbeing. (...) We propose that in ASMR cross‐activation of the map for affective (sensual) touch leads to an increase in subjective wellbeing and parasympathetic activity. Conversely, in misophonia the effect of the cross‐activation is to decrease emotional wellbeing and increase sympathetic activity. Our hypothesis also illuminates the connection between hearing and wellbeing more broadly and helps explain why so many people experience decreased wellbeing from modern urban soundscapes. (shrink)

'A mere metaphor', 'only symbolic', 'just a myth' - these tell tale phrases reveal how figurative language has been cheapened and devalued in our modern and postmodern culture. In God and the Creative Imagination, Paul Avis argues the contrary: we see that actually, metaphor, symbol and myth, are the key to a real knowledge of God and the sacred. Avis examines what he calls an alternative tradition, stemming from the Romantic poets Blake, Wordsworth and Keats and drawing on the (...) thought of Cleridge and Newman, and experience in both modern philosophy and science. God and the Creative Imagination intriguingly draws on a number of non-theological disciplines, from literature to philosophy of science, to show us that God is appropriately likened to an artist or poet and that the greatest truths are expressed in an imaginative form. Anyone wishing to further their understanding of God, belief and the imagination will find this an inspiring work. (shrink)

This article presents results from a simulation‐based study of inheritance inference, that is, inference from the typicality of a property among a “base” class to its typicality among a subclass of the class. The study aims to ascertain which kinds of inheritance inferences are reliable, with attention to the dependence of their reliability upon the type of environment in which inferences are made. For example, the study addresses whether inheritance inference is reliable in the case of “exceptional subclasses” (i.e., subclasses (...) that are known to be atypical in some respect) and attends to variations in reliability that result from variations in the entropy level of the environment. A further goal of the study is to show that the reliability of inheritance inference depends crucially on which sorts of base classes are used in making inferences. One approach to inheritance inference treats the extension of any atomic predicate as a suitable base class. A second approach identifies suitable base classes with the cells of a partition (of a preselected size k) of the domain of objects that satisfies the condition of maximizing the similarity of objects that are assigned to the same class. In addition to permitting more inferences, our study shows that the second approach results in inheritance inferences that are far more reliable, particularly in the case of exceptional subclasses. (shrink)

Huw Price’s subject naturalism has emerged as a leading pragmatist position within recent debates surrounding philosophical naturalism. Unlike orthodox views which tend to be guided by metaphysical questions about the “place” of, for instance, the mind, meaning, and morality within the natural world, subject naturalism focuses philosophical attention on language-users and the functions that certain concepts play within discursive practices. This paper considers two objections to subject naturalism and argues that they can be overcome by looking to the methodological insights (...) of philosophical genealogy. Although Price occasionally characterizes his project as a kind of genealogy, he offers little explanation of what such a methodological orientation is supposed to involve. I suggest that subject naturalists ought to remedy this theoretical lacuna by looking to the work of Bernard Williams. On the one hand, doing so can serve a diagnostic function: Williams’ conception of genealogy affords a perspective from which subject naturalism’s explanatory inadequacies are more clearly understood. On the other hand, Williams’ elaborated conception of genealogy represents a path by which the subject naturalist can overcome the shortcomings discussed in this paper. (shrink)

In Situations and Individuals, Paul Elbourne argues that the natural language expressions that have been taken to refer to individuals — pronouns, proper names, and definite descriptions — have a common syntax and semantics, roughly that of definite descriptions as construed in the tradition of Frege. In the course of his argument, Elbourne shows that proper names have previously undetected donkey anaphoric readings.This is contrary to previous theorizing and, if true, would undermine what philosophers call the direct reference theory (...) (which holds that the sole contribution of a proper name to the truth conditions of a sentence is an individual) as well as the related doctrine that proper names are rigid designators. Elbourne begins by addressing donkey anaphora, relating other concerns about pronouns to the solution of this notorious problem. His subsequent argumentation provides a unified semantics for the donkey anaphoric and bound and referential uses of pronouns and discusses the prospect of unifying the syntax and semantics of pronouns with the syntax and semantics of normal definite descriptions. Elbourne's aim is not only to advance his proposal of a unified syntax and semantics but also to urge linguists and philosophers dealing with pronoun interpretation to consider a wider range of theories than they do at present, and to test the competing claims of description-based theories and dynamic semantics against the data. (shrink)

The present paper introduces a simple framework for modeling the relationship between environmental states, perceptual states, and action. The framework represents situations where an agent’s perceptual state forms the basis for choosing an action, and what action the agent performs determines the agent’s payoff, as a function of the environmental conditions in which the action is performed. The framework is used as the basis for a simulation study of the sorts of correspondence between perceptual and environmental states that are important (...) for successful navigation of the world. Some of the results are surprising and conflict with long held views about the kind of perception-to-environment correspondence that is important for knowledge of the world. The results also raise doubts concerning the view that our perceptual states provide a basis for knowledge of the real structure of the external world. (shrink)

The relativist strain in Rorty’s work should be distinguished from the Davidsonian strain. The latter may be exploited in support of Rorty’s critique of philosophy but it is at odds with his use of “solidarity” and “ethnocentrism”as explanatory concepts. Once this is recognized, there remains in Rorty’s work a consistent challenge to the search for general philosophical theories of truth, objectivity, and rationality (of which relativism itself is an example). On this reading, however, Rorty’s pragmatism is not a theory that (...) offers answers to questions about the authority of beliefs and practices but rather a critical tool used to open detailed, concrete, and critical investigation into particular questions about the establishment and viability of the beliefs and practices we have. (shrink)

I here aim to show that a particular approach to the problem of induction, which I will call “induction by direct inference”, comfortably handles Goodman’s problem of induction. I begin the article by describing induction by direct inference. After introducing induction by direct inference, I briefly introduce the Goodman problem, and explain why it is, prima facie, an obstacle to the proposed approach. I then show how one may address the Goodman problem, assuming one adopts induction by direct inference as (...) an approach to the problem of induction. In particular, I show that a relatively standard treatment of what some have called the “Reference Class problem” addresses the Goodman Problem. Indeed, plausible and relatively standard principles of direct inference yield the conclusion that the Goodman inference (involving the grue predicate) is defeated, so it is unnecessary to invoke considerations of ‘projectibility’ in order to address the Goodman problem. I conclude the article by discussing the generality of the proposed approach, in dealing with variants of Goodman’s example. (shrink)

On the basis of knowledge prior to 1988, Ashbrook pointed out that whereas most men are primarily dependent on the left cerebral hemisphere (“dominant hemisphere”) for verbally related functions, women show a greater hemispheric balance in this respect. For men, he argues, their possession of a “speaking” and a “non‐speaking hemisphere” results in a positive‐negative, bipolar way of thinking that may be characterized as dualistic and dialectically hierarchical. In contrast, the greater balance of hemispheric function in women appears to promote (...) greater generalization and synthesis in their thinking.In this article I cite more recent neuroanatomical and brain imaging studies that provide further evidence of disparities in structure and function of the brains of men and women. As background for an attempt to explain these differences, I give a brief review of the triune evolution of the mammalian brain leading up to the human cerebrum. It is of major significance that the female has played a central role in mammalian evolution for more than 180 million years and that the evolutionary transition from reptilian therapsids to mammals is characterized by the develoment of (1) nursing conjoined with maternal care; (2) audiovocal communication or aiding mother‐offspring contact; and (3) play. In human beings, the infant‐carrying hypothesis suggests one means by which, over generations, certain parts of a woman's right hemisphere could undergo functional and eventual anatomical expansion. The mother‐infant communication of basic mammalian sounds with vowel and consonant components suggests a basis for the origination of speech.Finally, in an expansion of Ashbrook's original thesis, we arrive at the rovocative consideration that, unlike men, with their dialectical reasoning, women, with their more balanced brain, are provided with a trialectial ladder for climbing to achieve knowledge. In terms of quantum mechanics, the particle and wave would correspond to the substance and strength of the sides of the ladder, and the derived psychic information (which is neither matter nor energy) would compare to the rungs in between. (shrink)

Everything we experience and do as individuals is assumed to be a function of the nervous system. It is as though we were born with a total supply of algorithms for all given forms of psychic states and solutions for immediate or eventual actions. There is evidence that the forebrain is, so to speak, the central processor for psychic experience and psychologically directed behavior. Since information itself is immaterial, all forms of psychic experience represent immaterial emanations of the forebrain, including (...) sensations, perceptions, drives, affects, thoughts, and the precisely measured, cold hard facts of science. But it is to be emphasized that there can be no manufacture or communication of information without the intermediary of behaving entities. Because of the immateriality of information and the Gödel-like problem of self-reference, a central question arises as to whether or not we can ever rely on the brain with its viscoelastic properties to achieve a reliable yardstick for measuring time and space and the general nature of things. Most needed at the present time is a refined picture of the anatomy and chemistry of the brain’s circuitry accounting for its particular species of algorithms. Emphasis is given to the basic role of various proteins in generating subjective experience. Because of the role of resonance in contributing to the dynamical excitability of neural circuits, examples are given here of how it might play an algorithmic role at macroscopic, microscopic, molecular, and atomic levels. To describe this idea attention is focused on three evolutionary types of cortex that have developed in the triune evolution of the mammalian forebrain from the mammal-like reptiles to human beings. (shrink)

At a historic dialogue convened at the University of Richmond, Virginia, Baptist and secular humanist scholars in theology, history, philosophy, and the social sciences, came together to define shared concerns and common values. The dialogue focused on major areas of concern: academic freedom; social, political, and religious tolerance; biblical scholarship; separation of church and state; the social agenda of the Christian Coalition and the Southern Baptist Convention; the danger of militant fundamentalism; freedom of conscience and the historic and current role (...) of American Baptists; as well as the plight of pluralistic democracy. (shrink)

The thesis of this paper is that the Tractatus and the Investigations can be related as follows. Wittgenstein attempted in the Tractatus to avoid the conceptual realism of Frege and Russell with respect to propositions. He solved his problem by developing the picture-theory of language. This solution assumed that the units of language are words which arc names of simple objects. Because of this assumption the solution has the undesirable consequence that examples oi genuine names, atomic facts and atomic propositions (...) cannot be given although their existence is logically required by the solution. Wittgenstein had, therefore, eventually to examine the idea of a name. Thus the Philosophical Investigations in which this examination is conducted. (shrink)

Instead of searching for "African solutions" which have proved problematic so far, policymakers should focus on developing effective solutions for the complex challenges raised by the issue of armed conflict in Africa.

By applying markedness to Semitic morphology in a rigorous manner, this book brings to bear a venerable linguistic construct on a persistent philological crux, in order to achieve deeper clarity in the structures and workings of Canaanite and Hebrew verbs.

It is hypothesized that repeated, non‐invasive stimulation of the vestibular (balance) system, via a small electrical current to the skin behind the ears, will cause the brain centers that control energy homeostasis to shift the body toward a leaner physique. This is because these centers integrate multiple inputs to, in effect, fix a set‐point for body fat, which though difficult to alter is not immutable. They will interpret repeated stimulation of the parts of the vestibular system that detect acceleration as (...) a state of chronic activity. During such a physiologically challenging time it is preferable, from an energy homeostasis viewpoint, to both utilize fat reserves, and reduce the volume of these reserves and thus the energy cost of carrying them around. Hence, this type of vestibular stimulation could potentially be a therapeutic option for metabolic syndrome disorders such as obesity. This hypothesis is eminently testable via a clinical trial. (shrink)

This article is the attempt at a dialogue with Bruce McCormack about the position he espoused in The Cambridge Companion to Karl Barth concerning the relation between God's Election of grace and God's Triunity. I had criticized McCormack's position in my book, Divine Freedom and the Doctrine of the Immanent Trinity (2002), but I did not elaborate on it in great detail. To develop the dialogue I will: 1) consider McCormack's claim that in CD II/2 Barth made Jesus Christ “rather (...) than” the Eternal Logos the subject of election; 2) consider what Barth means when he speaks of Jesus Christ “in the beginning”; 3) compare McCormack's thesis that the Father never had regard for the Son, apart from the humanity to be assumed, with Barth's belief that we must not dispute the eternal will of God which “precedes even predestination”; 4) analyze in detail McCormack's rejection of Barth's belief that the logos asarkos in distinction from the logos incarnandus is a necessary concept in trinitarian theology; 5) discuss Barth's concept of the divine will in relation to the concept advanced by McCormack and suggest that McCormack has fallen into the error of Hermann Schell by thinking that God in some sense takes his origin from himself, so that God would only be triune if he elected us; 6) explain why it is a problem to hold, as McCormack does, that God's self-determination to be triune and his election of us should be considered one and the same act; and finally 7) explain McCormack's confusion of time and eternity in his latest article on the subject in the February, 2007 issue of the Scottish Journal of Theology, and his own espousal of a kind of indeterminacy on God's part (which he theoretically rejects). (shrink)

The molecular mechanism of temperature‐dependent sex determination (TSD) is a long‐standing mystery. How is the thermal signal sensed, captured and transduced to regulate key sex genes? Although there is compelling evidence for pathways via which cells capture the temperature signal, there is no known mechanism by which cells transduce those thermal signals to affect gene expression. Here we propose a novel hypothesis we call 3D‐TSD (the three dimensions of thermolabile sex determination). We postulate that the genome has capacity to remodel (...) in response to temperature by changing 3D chromatin conformation, perhaps via temperature‐sensitive transcriptional condensates. This could rewire enhancer–promoter interactions to alter the expression of key sex‐determining genes. This hypothesis can accommodate monogenic or multigenic thermolabile sex‐determining systems, and could be combined with upstream thermal sensing and transduction to the epigenome to commit gonadal fate. (shrink)

In this work Paul Murray explores which style of rationality is most appropriate to Christian theology in the contemporary pluralist, postfoundationalist, ...

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Health Care Ethics: A Comprehensive Christian Resource by James R. ThobabenPaul D. SimmonsHealth Care Ethics: A Comprehensive Christian Resource by James R. Thobaben Downers Grove, IL: Intervarsity Press, 2009. 429pp. $28.00In recent years, a stir has been created by the vocal and aggressive involvement of evangelicals in such issues as abortion, homosexuality, and end-of-life decisions. James Thobaben, the dean of Asbury Seminary, provides what he calls a [End (...) Page 203] “comprehensive resource” for evangelicals, and promises better understandings of their perspectives and commitments for those who are baffled or frustrated by the actions and claims of those on the religious right.Thobaben casts a wide net when defining those he includes as “evangelicals”—Southern Baptists, members of Campus Crusade, Pentecostals, the Holiness movement, neoevangelicals, charismatics, and Anabaptists. These diverse groups are evangelicals because of their “consistency on moral choices,” doctrinal orientation, and styles of social advocacy (24). Although they differ in a number of ways, they all share having been influenced in some way by John and Charles Wesley, Jonathan Edwards, and the Reformation. All stress conversion in that “one must say yes to the divine Jesus Christ” and become identified with the community of faithful believers (57). And in recent decades, they have become a potent political force with regard to the issues of abortion and homosexuality.Thobaben covers a wide range of topics in this book: from a general discussion of theodicy and healing to bioethics, disability, sickness, family and congregational care, professional truthfulness, managing care, end-of-life decisions, assisted reproduction, organ donation, and death. Yet, although he claims to provide a “comprehensive resource” on evangelical Christian health care ethics, he fails to provide a thorough examination of his subject matter. For example, Thobaben pays little attention to the historic beginnings of the religious right. One misses any mention of political action groups or the coalitions formed with or by conservative Christian groups to pursue social reforms, or of why such disparate groups have cooperated for political or social goals under the same umbrella. He focuses solely on identifying and articulating the consensus among those who embrace certain moral values on the current scene. Thobaben’s uncritical approach to his subject matter leaves the impression that this book is essentially an apology for evangelical, right-wing Christian social thought. One searches in vain for any critical discussion of the beliefs and values he presents or any thoughtful engagement with those who might view the stances he presents as an assault against women’s rights or an attack on the rights of gays, lesbians, and transsexuals.Moreover, in a book like this, one would have expected a more careful assessment of biblical passages and historical precedents. Thobaben does not provide much rationale for his method for moving from the Bible to current social issues. For example, no prohibition against abortion is found in the Bible and the few passages about homosexual practices hardly add up to the fierce opposition to gays found among strident evangelicals. Moreover, Thobaben does not mention that in 1965 laws against contraceptives were declared unconstitutional by the Griswold vs. Connecticut decision, the Supreme Court’s rejection of a ban supported by an evangelical crusade led by Anthony Comstock. [End Page 204]It is interesting to note that Thobaben holds a strongly qualified commitment to religious liberty and only a “thin” version of the social contract basic to the Bill of Rights (37). He argues that in at least some situations “intolerance is not only morally understandable but strongly preferable,” as in the examples of the “abolition of slavery and prolife/antiabortion advocacy” (29) or, in another context—where he distinguishes between tolerance toward those outside the church and intolerance toward those within it—with regard to homosexuality and alcohol intoxication (30).The task of Christian ethics is to enlighten believers and the general citizenry by a careful exposition of the sources of wisdom available to those who want to think and think morally about issues of importance to human flourishing. That task is especially important in an age of demagogic hostility toward unpopular groups. Sadly, this book does not engage such critical questions. It may prove... (shrink)

There are two central distinctions upon which the present argument is predicated. First is the distinction between two correlative aspects of what is involved in a value-judgment or in an “experiencing” of value: actualized-value and value-ideal. This we find to be a distinction without which all attempt at clear talk about “value” is so hopelessly ambiguous as to be unintelligible. Second is the distinction between property-platonism and platonism-proper. After these two sets of distinctions have been explicated, our thesis will be (...) pursued: Moore is not a value-platonist-proper at all, because his famous “non-natural” property, goodness, is not a value-ideal. Moore is merely a value-property-platonist. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:SOME DOGMATIC CONSEQUENCES OF PAUL F. KNITTER'S UNITARIAN THEOCENTRISM PAUL D. MOLNAR St. John's University Jamaica, New York EACTIONS TO Paul Knitter's No Other Nanie? vary from criticizing his "unitarian theocentrism" 1 and his sliding away from "creedal Chrisitology" 2 to unequivocail endorsement of his" less Christocentric approach to a theo1ogy of religions;" 3 this shows the challenge Knitter poses to current dogmatics. This 1arHcile w1ll (...) explore three critical dogmatic issues related to Knitter's non-normative ChristoJogy. First, can the idea that Jesus is one savior among others be defonded froni within the Christian-Catholic 1tradition without yie1ding the truth of Christology? Second, if "Jesus remains universailly normativ ;e " for Christians while " other revelations or rev;ea:lers might also be universaUy normative," then does this not p:vomote some form of docetic Christology and lead to a unitarianism, exduded by the naiture of the God revealed in Christ? Third, on the basis of " l'eligious experience " Knitter olaims to perceive an" evolution from ecolesiocentrism to chrfatocentrism to theocentrism" and finally to "soteriooentrism." 4 Is there 1!1ea1ly such an evolution? And if there is noit, oan those who de- ~end the tradition succeed by arguing from experience and praxis rather than from revelation and faith? 5 Moreover, if 1"Review Symposium: Paul Knitter's No Other Name?: A Critical Survey of OMistian Attitudes toward the World Religions," in Horizons 13 (1986): 116-135. This is the view of Daniel Sheridan, p. llS. 2 This is the view of Denise Carmody. Ibid., p. 122. s This is the view of William Cenkner. Ibid., p. 127. 4 Ibid., pp. 133-34. 5 Denise Carmody, e.g., believes that we should stress praxis more than 449 450 PAUL D. MOLNAR we think the tradition should not be defended, have we not ceased to think about theological truth? Rather, have we not made divinity itself indis:tingiuishab1e from our human experiences and praxis at the outset? And does this not open the door to both polytheism allJd pantheism? By making God hut noit Christ normative, Knitter's " nonnormati ¥e" Christology re-1transiates the truth of Jesus' oonsubstantiality with the Father into the content of a myth, an experienice or a vailue judgment having no re1ality in itseH.6 It then defines :reveiLation and salvation.aocording to a unitarian view of God. While Knitter denies this,7 his reasoning aictuaUy is unitarian: In my proposed model, Jesus remains universally normative, but I am asking whether Christians can recognize that other revelations or revealers might also be universally normative. Could there be a complementary uniqueness among the religious traditions of the world? To try to answer that question, 'intellectual conversion;... is a requisite. But it will have to be an intellectual conversion that walks more than' the way to Nicea and Chalcedon'... only on the basis of the praxis of authentic dialogue-grounded in intellectual, moral, and religious conversion-can we know the unique~ ness of Christ.8 doctrine without relativizing Christ. Thus, for her, Rahner's Christology does not mean " that Christians cannot be open to the Buddha or Lord Krishna," Ibid., p. 126. The problem is that this very thinking already relativizes Christ. 6 Even theologians who do not intend the radical views of John Hick run a similar risk by beginning Christology from below in the manner of Paul Knitter. Cf., e.g., Edward L. Krasevac, O.P., "' Christology From Above' And 'Christology From Below '," The Thomist, 51 (1987) : 299-306, arguing that "Christological faith is an apostolic faith that has its origins in a historical process which began with the public ministry of our Lord...." (p. 300) causes us to ask what makes Christology true? Is it "the actual apostolic process " (306) or is it Jesus as the Lord who is and remains the sole foundation and validation for faith in any age? Does this approach not leave the door open to the kind of evolution which Knitter claims to have discovered in Christianity, which then enables him to move beyond Jesus as the only Lord and Savior? 1 Review Symposium, Horizons, p. 131. s Ibid., p. 133. KNITTER'S UNITARIAN THEOCENTRISM 451 Here the ha:.sis... (shrink)